{"id":9445,"date":"2023-03-15T23:19:37","date_gmt":"2023-03-15T23:19:37","guid":{"rendered":"https:\/\/www.goodacademic.com\/blog\/questions\/research-proposal-with-something-to-do-with-immune-response-with-organ-transplants\/"},"modified":"2023-03-15T23:19:37","modified_gmt":"2023-03-15T23:19:37","slug":"research-proposal-with-something-to-do-with-immune-response-with-organ-transplants","status":"publish","type":"questions","link":"https:\/\/www.goodacademic.com\/blog\/questions\/research-proposal-with-something-to-do-with-immune-response-with-organ-transplants\/","title":{"rendered":"Research Proposal with something to do with Immune response with organ transplants"},"content":{"rendered":"

BIOL 415L Research Proposal Final Draft Instructions<\/p>\n

Note: It is highly recommended that students use the assignment rubric published on Canvas and the<\/div>\n
scientific writing tips included in the laboratory manual as resources. In addition, a review session will be<\/div>\n
held prior to the first research proposal deadline to discuss how to select an appropriate topic and how<\/div>\n
to construct effective sections of the research proposal; students who attend the review session<\/div>\n
historically perform better on this assignment.<\/div>\n
I) Topic \u00e2\u20ac\u201c the research topic is limited to the field of cell biology (i.e., cell signaling, organelle<\/div>\n
function, protein function, molecular interactions), and preferably, biomedical research relating to<\/div>\n
human health\/disease.<\/div>\n
A) The following topics are off-limits:<\/div>\n
i) Developing a scientific method\/technique\/assay\/reagent<\/div>\n
ii) Clinical trials\/experiments on human subjects<\/div>\n
iii) Behavioral studies on animals<\/div>\n
iv) The topics proposed in the review session<\/div>\n
II) Content \u00e2\u20ac\u201c The research proposal should include the following sections.<\/div>\n
A) Background and Rationale:<\/div>\n
i) The opening sentence should concisely present the research topic while capturing the<\/div>\n
audience\u00e2\u20ac\u2122s attention; utilizing statistics is a common approach to establishing the necessity<\/div>\n
for the proposed research.<\/div>\n
ii) The following paragraph(s) should concisely summarize at least two peer-reviewed, primary<\/div>\n
research articles that establish the current limit of knowledge in the field of interest. This<\/div>\n
section should be structured from a wide to narrow research scope, logically building a case<\/div>\n
and providing justification for the proposed research. This summary should conclude with a<\/div>\n
gap in knowledge statement, using similar language to: \u00e2\u20ac\u0153there remains a gap in knowledge<\/div>\n
as to…\u00e2\u20ac\ufffd<\/div>\n
iii) This section should mention the translational connection to biomedical research (i.e., how<\/div>\n
the research, if successful, will benefit human health).<\/div>\n
iv) This section should conclude with a statement summarizing the proposed research and how,<\/div>\n
if successful, it will fill the gap in knowledge.<\/div>\n
B) Specific Aim:<\/div>\n
i) The specific aim statement must be a single sentence, using similar language to: \u00e2\u20ac\u0153the aim of<\/div>\n
the proposed research is to…\u00e2\u20ac\ufffd<\/div>\n
ii) The specific aim must be narrow in focus, seeking to uncover one new piece of data related<\/div>\n
to the gap in knowledge.<\/div>\n
iii) The specific aim should concisely and clearly describe the goal of the experiment, including<\/div>\n
details such as the cell line\/animal model, drug\/treatment condition (and specific<\/div>\n
concentration), and the expected outcome.<\/div>\n
C) Hypothesis:<\/div>\n
i) The hypothesis statement must be a single sentence, using similar language to: \u00e2\u20ac\u0153we<\/div>\n
hypothesize that…\u00e2\u20ac\ufffd<\/div>\n
ii) The hypothesis should directly reflect and complement the wording of the specific aim.<\/div>\n
iii) The hypothesis must be testable by the experiments proposed in the Experimental Design<\/div>\n
section.<\/div>\n
D) Experimental Design:<\/div>\n
i) This section should provide a concise and clear description of all experiments necessary to<\/div>\n
fully test the hypothesis.<\/div>\n
ii) This section should include all of the following components, when appropriate: positive and<\/div>\n
negative controls, sample sizes with justification, names\/origins of cell lines and\/or animal<\/div>\n
models, number of replicates, and sources of key reagents (i.e., vendor, publication).<\/div>\n
iii) The proposed experiments must be feasible.<\/div>\n
iv) The proposed experiments must be devoid of fatal flaws (i.e., if one aspect of the proposal<\/div>\n
fails, it should not affect the other aspects).<\/div>\n
v) Aspects of the experimental design applied from prior publications must be adequately<\/div>\n
summarized and include proper in-text citations.<\/div>\n
vi) This section should conclude with expected results from each experiment, and how each<\/div>\n
aspect of the experimental design will inform the hypothesis.<\/div>\n
E) Potential Pitfalls and Alternative Approaches:<\/div>\n
i) This section should identify and describe one aspect of the proposed research plan that may<\/div>\n
not succeed as anticipated (i.e., a potential pitfall), and should describe how the research<\/div>\n
plan as a whole would be impacted as a result.<\/div>\n
ii) In response to the pitfall identified, this section should also include at least one alternative<\/div>\n
approach (i.e., related assay, technique) that could be employed to achieve the same<\/div>\n
experimental goal, should the pitfall actually take place.<\/div>\n
iii) This section should be limited to 3-4 sentences.<\/div>\n
III) Formatting<\/div>\n
A) The length should be 2-3 pages, not including references.<\/div>\n
B) The proposal should be typed, double-spaced, in 11-point Arial font, with 1 inch margins.<\/div>\n
C) References must follow the Journal of Cell Biology (JCB) formatting requirements for both the<\/div>\n
bibliography and in-text citations.<\/div>\n
D) A total of at least five references must be used, two of which must be primary research articles<\/div>\n
published in 2015 or later.<\/div>\n","protected":false},"excerpt":{"rendered":"

BIOL 415L Research Proposal Final Draft Instructions Note: It is highly recommended that students use the assignment rubric published on Canvas and the scientific writing tips included in the laboratory manual as resources. In addition, a review session will be held prior to the first research proposal deadline to discuss how to select an appropriate […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":[],"disciplines":[275],"paper_types":[],"tagged":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/questions\/9445"}],"collection":[{"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/questions"}],"about":[{"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/types\/questions"}],"author":[{"embeddable":true,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/comments?post=9445"}],"version-history":[{"count":0,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/questions\/9445\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/media?parent=9445"}],"wp:term":[{"taxonomy":"disciplines","embeddable":true,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/disciplines?post=9445"},{"taxonomy":"paper_types","embeddable":true,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/paper_types?post=9445"},{"taxonomy":"tagged","embeddable":true,"href":"https:\/\/www.goodacademic.com\/blog\/wp-json\/wp\/v2\/tagged?post=9445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}