<\/p>\n
MAARIE Template for Evaluating Evidence Based Health Research (please use attached template)<\/strong><\/p>\n <\/p>\n Method- The purpose and population for the investigation<\/u> 2. Study population <\/p>\n 3. Sample size and statistical power<\/strong> <\/p>\n Assignment- Selection of participants for the study and control groups<\/u> 2. Confounding variables<\/strong> 3. Masking or blinding<\/strong> <\/p>\n Assessment-<\/u> Measurement of outcomes or endpoints in the study and control groups<\/u> 2. Accurate and precise 3. Complete and unaffected by observation <\/p>\n Results- Comparison of outcomes in the study and control groups<\/u> 2. Inference 3. Adjustment <\/p>\n Interpretation- Meaning of the results for those included in the investigation<\/u> <\/p>\n 2. Harms 3. Subgroups and interactions <\/p>\n Extrapolation- Meaning for those not specifically included in the investigation<\/u> Rev. 2021<\/p>\n Riegelman, R.K. & Nelson, B.A. (2021). Studying a study & testing a test. <\/em>Wolters Kluwer.<\/p>\n Bovbjerg, M. L., Cheyney, M., & Everson, C. (January 01, 2016). Maternal and Newborn Outcomes Following Waterbirth: The Midwives Alliance of North America Statistics Project, 2004 to 2009 Cohort.<\/strong> Journal of Midwifery & Women’s Health,<\/strong><\/em> 61,<\/strong><\/em> 1, 11-20.<\/strong><\/p>\n
\n 1. Study hypothesis<\/strong>
\n What is the study question being investigated?<\/p>\n
\n What population is being investigated and what are the inclusion and exclusion criteria for the participants of the investigation?<\/p>\n
\n How many individuals are included in the study and in the control groups? Are the numbers adequate to demonstrate statistical significance if the study hypothesis is true (what is the statistical power)?<\/p>\n
\n 1. Process<\/strong>
\n What method is used to identify and assign individuals or populations to study and control groups?<\/p>\n
\n Are there differences between study and control groups, other than the factor being investigated, that may affect the outcome of the investigation?<\/p>\n
\n Are the participants and\/or the investigators aware of the participants’ assignment to a particular study or control group?<\/p>\n
\n 1. Appropriate
\n Does the measurement of outcomes address the study’s question?<\/p>\n
\n Is the measurement of outcomes an accurate and precise measure of the phenomenon that the investigators seek to assess?<\/p>\n
\n Is the outcome measurement nearly 100% complete and is it affected by the participants\u2019 or the investigators\u2019 knowledge of the study group or control group assignment?<\/p>\n
\n 1. Estimation
\n What is the magnitude or strength of the relationship observed in the investigation?<\/p>\n
\n What statistical technique(s) are used to perform statistical significance testing?<\/p>\n
\n What statistical technique(s) are used to take into account or control for differences between the study group and the control group that may affect the results?<\/p>\n
\n 1. Contributory cause or efficacy
\n Does the factor being investigated alter the probability that the disease will occur (contributory cause) or work to reduce the probability of undesirable outcomes (efficacy)?<\/p>\n
\n Are adverse events that affect the meaning of the results identified?<\/p>\n
\n Do the outcomes in subgroups differ and are there interactions between factors that affect outcomes?<\/p>\n
\n 1. To similar individuals, groups, or populations<\/strong>
\n Do the investigators extrapolate or extend the conclusions to individuals, groups, or populations that are similar to those who participated in the investigation?<\/p>\n
\n 2. Beyond the data<\/strong>
\n Do the investigators extrapolate by extending the conclusions beyond the dose, duration, or other characteristics of the investigation?<\/p>\n
\n 3. To other populations<\/strong>
\n Do the investigators extrapolate to populations or settings that are quite different from those in the investigation?<\/p>\n